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KMID : 1132720070050010019
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Genomics & Informatics
2007 Volume.5 No. 1 p.19 ~ p.23
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Regression Models for Haplotype-Based Association Studies
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Oh So-Hee
Namkung Jung-Hyun
Park Tae-Sung
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Abstract
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In this paper, we provide an overview of statistical models for haplotype-based association studies, and summarize
their features based on the design matrix. We classify the design matrix into the two types: direct and indirect. For these two kinds of matrices, we present and compare characteristics using a simple hypothetical example, and a real data set. The motivation behind this study was to provide practitioners with an improved understanding, to facilitate the informed selection of the appropriate haplotype-based model and to improve the interpretability of the models.
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KEYWORD
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Association, Case-control Study, Design Matrix, Generalized Linear Model, Haplotype
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